Fast Optimization of Temperature Focusing in Hyperthermia Treatment of Sub-Superficial Tumors

Microwave hyperthermia aims at selectively heating cancer cells to a supra-physiological temperature. For non-superficial tumors, this can be achieved by means of an antenna array equipped with a proper cooling system (the water bolus) to avoid overheating of the skin. In patient-specific treatment planning, antenna feedings are optimized to maximize the specific absorption rate (SAR) inside the tumor, or to directly maximize the temperature there, involving a higher numerical cost. We present here a method to effect a low-complexity temperature-based planning. It arises from recognizing that SAR and temperature have shifted peaks due to thermal boundary conditions at the water bolus and for physiological effects like air flow in respiratory ducts. In our method, temperature focusing on the tumor is achieved via a SAR-based optimization of the antenna excitations, but optimizing its target to account for the cooling effects. The temperature optimization process is turned into finding a SAR peak position that maximizes the chosen temperature objective function. Application of this method to the 3D head and neck region provides a temperature coverage that is consistently better than that obtained with SAR-optimization alone, also considering uncertainties in thermal parameters. This improvement is obtained by solving the bioheat equation a reduced number of times, avoiding its inclusion in a global optimization process

Automated Design of a Broadside-Radiating Linearly Polarized Isotropic Metasurface Antenna

We present the automated design of a broadside-radiating metasurface antenna. The design is carried out by employing a continuous isotropic Impedance Boundary Condition through an optimization procedure based on the equivalent surface current only. A modified gradient-descent optimization algorithm is applied to minimize an objective function that incorporates both realizability and far field requirements. The antenna is then implemented by a suitable arrangement of circular unit cells, selected from a database of precomputed shapes. This procedure is applied to the design of a broadside-radiating, linearly polarized circular metasurface antenna working at 23 GHz, with size ≈12λ . The obtained design is then validated with commercial software simulations

Correction of moisture effects on near infrared calibration for the analysis of phenol content in eucalyptus wood extracts

Les méthodes basées sur la spectroscopie proche infrarouge pour estimer les propriétés du bois sont sensibles aux variations des paramètres physiques (température, granulométrie. . . ). Le bois étant un matériau hygroscopique sensible, l'influence de l'humidité sur l'absorbance et l'étalonnage proche infrarouge a été étudiée afin de mieux considérer les possibilités d'applications dans des conditions réelles.Un étalonnage de référence de la quantité de polyphénols présents dans les extraits a été établi à partir de spectres d'une collection de bois d'hybrides d'Eucalyptus urophylla × E. grandis à humidité constante fixée. D'autres spectres ont été obtenus sur des échantillons de même provenance mais à 8 teneurs en eau couvrant une large plage de variation. L'influence de l'humidité sur l'absorbance proche infrarouge puis sur l'estimation par le modèle de référence a été analysée. / Methods based on near infrared spectroscopy used to assess wood properties are susceptible to variations in physical parameters (temperature, grain size, etc). As wood is a hygroscopically sensitive material, we studied the effects of moisure on near infrared absorbance and calibration to accurately determine the application potential of this technique under routine. A collection of Eucalyptus urophylla x E. grandis hybrid wood pieces were analysed to obtain reference calibration of polyphenol contents in wood extracts via NIR spectra acquired under constant moisture conditions.Others specimens from the same source were assessed to obtain spectra for eight moisture contents spanning a broad variation range. The effects of moisture on absorption and on estimates based on a reference model were analysed. An increase in moisture content prompteda rise in near infrared absorption over the entire spectrum and the water O-H absorption bands. The polyphenol content estimates obtained by assessing specimens against the reference calibration at variable moisture contents revealed prediction bias. Five correction methods were then tested on enhance the robustness relative to moisture. In-depth calibration and external parameter orthogonalization were found to be the most efficient methods for offsetting this factor

Oakscan: procédé de mesure rapide et non destructif des polyphénols du bois de chêne de tonnellerie

Les polyphénols extractibles contenus dans le bois de chêne des barriques de tonnellerie sont des composés très importants car ils ont une influence sur la couleur et sur les propriétés organoleptiques des vins qu'ils enrichissent. Les analyses chimiques de laboratoire qui permettent de les mesurer sont réalisées sur des extractions, nécessitent un délai de réalisation très long et ne permettent d'analyser que des lots de matière par échantillonnage. Le procédé de mesure rapide et non destructif Oakscan® a été développé par la tonnellerie Radoux. Il se fonde sur la spectrométrie proche infrarouge et permet de mesurer la teneur en polyphénols en quelques secondes, directement sur le bois massif. Le contenu polyphénolique de chaque douelle est alors mesuré, permettant une meilleure maitrise de la matière première entrant dans la composition des fûts

Radiation and Scattering of EM Waves in Large Plasmas Around Objects in Hypersonic Flight

Hypersonic flight regime is conventionally defined for Mach> 5; in these conditions, the flying object becomes enveloped in a plasma. This plasma is densest in thin surface layers, but in typical situations of interest it impacts electromagnetic wave propagation in an electrically large volume. We address this problem with a hybrid approach. We employ Equivalence Theorem to separate the inhomogeneous plasma region from the surrounding free space via an equivalent (Huygens) surface, and the Eikonal approximation to Maxwell equations in the large inhomogeneous region for obtaining equivalent currents on the separating surface. Then, we obtain the scattered field via (exact) free space radiation of these surface equivalent currents. The method is extensively tested against reference results and then applied to a real-life re-entry vehicle with full 3D plasma computed via Computational Fluid Dynamic (CFD) simulations. We address both scattering (RCS) from the entire vehicle and radiation from the on-board antennas. From our results, significant radio link path losses can be associated with plasma spatial variations (gradients) and collisional losses, to an extent that matches well the usually perceived blackout in crossing layers in cutoff. Furthermore, we find good agreement with existing literature concerning significant alterations of the radar response (RCS) due to the plasma envelope

Radiation and Scattering of EM Waves in Large Plasmas Around Objects in Hypersonic Flight

Hypersonic flight regime is conventionally defined for Mach larger than 5; in these conditions, the flying object becomes enveloped in a plasma. This plasma is densest in thin surface layers, but in typical situations of interest it impacts electromagnetic wave propagation in an electrically large volume. We address this problem with a hybrid approach. We employ Equivalence Theorem to separate the inhomogeneous plasma region from the surrounding free space via an equivalent (Huygens) surface, and the Eikonal approximation to Maxwell equations in the large inhomogeneous region for obtaining equivalent currents on the separating surface. Then, we obtain the scattered field via (exact) free space radiation of these surface equivalent currents. The method is extensively tested against reference results and then applied to a real-life re-entry vehicle with full 3D plasma computed via Computational Fluid Dynamic (CFD) simulations. We address both scattering (RCS) from the entire vehicle and radiation from the on-board antennas. From our results, significant radio link path losses can be associated with plasma spatial variations (gradients) and collisional losses, to an extent that matches well the usually perceived blackout in crossing layers in cutoff. Furthermore, we find good agreement with existing literature concerning significant alterations of the radar response (RCS) due to the plasma envelope

Single Event Upset tests and failure rate estimation for a front-end ASIC adopted in high-flux-particle therapy applications

none8A 64 channels Application Specific Integrated Circuit, named TERA09, designed in a 0.35 m technology for particle therapy applications, has been characterized for Single Event Upset probability. TERA09 is a current-to-frequency converter that offers a wide input range, extending from few nA to hundreds of A, with linearity deviations in the order of a few percent. This device operates as front-end readout electronics for parallel plate ionization chambers adopted in clinical applications. This chip is going to be located beside the monitor chamber, thus not directly exposed to the particle beam. For this reason, no radiation hardening techniques were adopted during the microelectronics design. The intent of the test reported in this paper is to predict the TERA09 upset rate probability in a real application scenario. Due to the fact that TERA09 has an extended digital area with registers and counters, it is interesting to estimate the effect of the secondary neutron field produced during the treatment. The radiation damage test took place at the SIRAD facility of the Italian National Institute for Nuclear Physics in Padova, Italy. The SIRAD facility allows to study the CMOS upset rate as a function of the energy deposited during irradiation. By irradiating the chip with ions of different Linear Energy Transfer, it is possible to calculate the single event effect cross-section as a function of the deposited energy. It resulted that the minimum deposited energy in a CMOS silicon sensitive volume of , responsible for a Single Event Upset probability higher than zero, is 690 keV. In the last part of the paper, we calculated the expected upset probability in a typical clinical environment, knowing the fluence of secondary, backward-emitted neutrons. Considering as an example a treatment room located at the CNAO particle therapy center in Pavia, the expected upset rate for TERA09 is events/year. Using a redundant and independent monitor chamber, the upset probability expected during one detector readout is lower than , as explained in the document.noneFausti, F.; Mazza, G.; Giordanengo, S.; Hammad Ali, O.; Manganaro, L.; Monaco, V.; Sacchi, R.; Cirio, R.Fausti, F.; Mazza, G.; Giordanengo, S.; Hammad Ali, O.; Manganaro, L.; Monaco, V.; Sacchi, R.; Cirio, R